Aussie scientists develop injectable treatment to help flat-nosed dogs breathe easier

Thursday, 23 April 2026 20:30

Short-nosed dogs could soon be able to breathe easier thanks to a new injection developed by Australian scientists.

Almost half of all Pugs, French and British Bulldogs suffer from chronic respiratory condition Brachycephalic Obstructive Airway Syndrome (BOAS), which progressively impacts their ability to breathe, eat, exercise and sleep.

In severe cases, the condition can also shorten their life up to four years.

"Decades of selective breeding for the popular flat-faced appearance have unfortunately led to serious breathing problems," he said. 

Most affected dogs, like Pugtato, require surgery to widen the nostrils and remove excessive throat tissue to help their breathing.

"He was absolutely struggling to breathe and I actually thought he was going to die," Pugtato's owner Joanna Herceg said.

"He dropped seven or eight kilograms but still he was struggling.

"The surgery improved him a little bit but he still wasn't good."

Out of options, Pugtato was one of six pugs and bulldogs to take part in an early trial of a new oral treatment for dogs who struggled to complete a brisk three-minute walk.

Developed by biotech company Snoretox and RMIT University in Melbourne, the SnoreTox-1 trial is hoping to provide a less-invasive alternative to help with breathing.

The dogs were sedated before an injection of Snoretox-1 was given under their tongue.

The trial found owners began noticing reduced breathing noise and effort when walking after just 10 days.

For Pugtato, it was even quicker.

"We did the Snoretox injection and literally within a few days I started to notice his breathing improving," Herceg said.

"He went from a dog who struggled everyday and was really loud...to a dog that's active, happy, plays and his breathing's drastically improved"

The SnoreTox-1 technology is described as "the opposite of Botox" and works by strengthening airway muscles to help support the throat to maintain airflow.

"What it does is the opposite of Botox. It makes the muscles at the floor of the mouth a little stronger, " Snoretox Managing Director and RMIT Adjunct Professor Tony Sasse said.

It has been in development for 15 years.

For some of the dogs the treatment lasted more than six months.

Now researchers are hoping to ramp up trials in the middle of the year, with the aim of eventually getting the treatment approved for wider use.

"Further research and regulatory approvals are required before the treatment can be offered more widely, but these positive results provide an early indication that we are on the right path," Sasse said.

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