Hours later Trump took to social media again to predict "Iran and Israel should make a deal, and will make a deal".
US President Donald Trump has issued a stark warning to Iran against retaliating on US targets in the Middle East while also predicting Israel and Iran would "soon" make a deal to end their escalating conflict.
Trump in an early Sunday morning (late Sunday AEST) social media post said the US "had nothing to do with the attack on Iran" as Israel and Iran traded missile attacks for the third straight day.
Iran, however, has said it would hold the US – which has provided Israel with much of its deep arsenal of weaponry – for its backing of Israel.
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Israel targeted Iran's Defence Ministry headquarters in Tehran and sites it alleged were associated with Iran's nuclear program, while Iranian missiles evaded Israeli air defences and slammed into buildings deep inside Israel.
"If we are attacked in any way, shape or form by Iran, the full strength and might of the US Armed Forces will come down on you at levels never seen before," Trump said.
Hours later Trump took to social media again to predict "Iran and Israel should make a deal, and will make a deal".
The US president argued he built a track record for de-escalating conflicts, and that he would get Israel and Iran to cease hostilities "just like I got India and Pakistan to make" after the two countries' recent cross-border confrontation.
India struck targets inside Pakistan after militants in April massacred 26 tourists in Indian-controlled Kashmir. Pakistan has denied any links to the attackers. Following India's strikes in Pakistan, the two sides exchanged heavy fire along their de facto borders, followed by missile and drone strikes into each other's territories, mainly targeting military installations and airbases.
It was the most serious confrontation in decades between the countries. Trump on Sunday repeated his claim, disputed by India, that the two sides agreed to a ceasefire after he had offered to help both nations with trade if they agreed to de-escalate.
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Trump also pointed to efforts by his administration during his first term to mediate disputes between Serbia and Kosovo and Egypt and Ethiopia.
"Likewise, we will have PEACE, soon, between Israel and Iran!" Trump said.
"Many calls and meetings now taking place. I do a lot, and never get credit for anything, but that's OK, the PEOPLE understand. MAKE THE MIDDLE EAST GREAT AGAIN!"
The growing conflict between Israel and Iran is testing Trump who ran on a promise to quickly end the brutal wars in Gaza and Ukraine and build a foreign policy that more broadly favours steering clear of foreign conflicts.
Trump has struggled to find an endgame to the wars in Ukraine and Gaza.
And after criticising former US president Joe Biden during last year's campaign for preventing Israel from carrying out strikes on Iranian nuclear sites, Trump found himself making the case to the Israelis to give diplomacy a chance.
His administration's push on Tehran to give up its nuclear program came after the US and other world powers in 2015 reached a long-term, comprehensive nuclear agreement that limited Tehran's enrichment of uranium in exchange for the lifting of economic sanctions.
Trump spoke with Russian President Vladimir Putin on Saturday about the growing Israel-Iran conflict. And Trump is set to travel later on Sunday (Monday AEST) to Canada for Group of Seven leaders summit where the Middle East crisis will loom large over his talks with the leaders of Britain, Canada, France, Germany, Italy, and Japan and the European Union.
Some influential backers of Trump are urging him to keep the US out of Israel's escalating conflict with Iran.
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