The potential new evidence could be linked with the unidentified person who appeared outside the 84-year-old's home on the night she went missing.
Authorities in the south-western United States searching for Nancy Guthrie have reportedly found a pair of mystery black gloves in a potential new lead.
The missing 84-year-old mother of US TV anchor Savannah Guthrie was believed to have been abducted from her home in Tucson, Arizona 12 days ago.
Video from the New York Post on Thursday (Friday AEDT) shows investigators picking up one of the gloves from the side of a road, reportedly about three kilometres from Nancy's home.
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Reporter Georgia Worrell said she and the photographer working with her saw a black object on the side of the road, and as they got closer, they thought it might be a glove.
"It had just been discarded on the side of the road," Worrell told CNN.
It wasn't until after they were able to see the photographer's high-resolution photos that they confirmed it was a glove.
The item was bagged as evidence, Worrell said.
It is not clear whether authorities believe it to be the same glove worn by the person seen in doorbell camera footage outside Guthrie's home on the night she went missing, released by the FBI.
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Former FBI special agent Andy Black, who was stationed in Tucson, said DNA testing of the glove would be crucial for the investigation.
"They're going to look to see if they get any type evidence on those gloves. That ties it to the residence," he told Today this morning.
"It could be blood from Nancy Guthrie. and that opens up the door for get from those DNA ... This could be a break in the case."
Guthrie was last seen at her home in Tucson on January 31, and since then law enforcement agencies have received numerous leads.
On Thursday, a white tent was put in place directly outside the front door of the property before being taken down shortly afterwards.
Investigators were also seen packing up a large black case along with other items they had brought into the home.
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